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BREAST CANCER FAQs

Why is radiation recommended after the tumor is surgically removed?

Surgery to remove the tumor and preserve the remaining breast tissue is called a lumpectomy. Radiation treatment is given to destroy any remaining microscopic deposits of cancer in and around the site of surgery. The combination of lumpectomy followed by radiation therapy is considered equal or better than a mastectomy, which is a major surgery removing the entire breast. If radiation is not done following a lumpectomy, there is a high likelihood of cancer growing back in the breast and a lower survival.

How can I save my breast and have better results?

Many women are surprised to learn that breast cancer research has already shown us that mastectomy offers no survival advantage (and may even be worse) compared to lumpectomy and radiation. Many women also do not appreciate that even the best possible reconstruction after a mastectomy can not match the excellent appearance of a breast treated with lumpectomy and radiation. We would be more than happy to educate you further about current breast cancer research during your consultation.

Can I avoid major surgery like a mastectomy?

Yes, absolutely. Our mission is to educate women about this and improve their lives as a result. Mastectomy is disfiguring and totally unnecessary for the vast majority of women today. This is especially true since many women who are getting regular mammograms are uncovering tumors that can be easily removed while sparing the normal breast. Even women who are told they have 'large' tumors or cancerous lymph nodes can still spare their normal breast because of research demonstrating excellent results including survival and appearance, making a mastectomy 'obsolete' in all but the most extreme cases.

What are the common side effects of radiation therapy to the breast?

Side effects can include fatigue, skin irritation similar to a moderate sunburn, and mild to moderate breast swelling. These changes are temporary and can be treated by skin creams and/or medications. Tell your radiation oncologist or nurse about any discomfort you may feel, we will help you through it. Most women are surprised how quickly and easily they complete radiation.

Why is modern radiation successful in decreasing side effects and improving cancer control?

Modern radiation involves computer controlled dose modulation that can actually reduce extremes in radiation in the breast and on the skin such that the dose is much more homogenous and you experience less skin burning. More importantly it allows for better heart and lung protection. The breast also has less areas of under dosing so tumor control is expected to be higher.

What is accelerated partial breast irradiation (APBI) and who is a candidate?

Accelerated partial breast irradiation is the delivery of radiation to only part of the breast over four to five days. By treating a smaller area of the breast, treatment can be completed in just one week.

Randomized clinical trials are being conducted to evaluate the effectiveness of this treatment, and until then, only women who are not candidates for the clinical trial should be considered for APBI off-study. Selected women who are at the lowest risk of recurrence (recurrence means the cancer coming back) may be offered APBI. Researchers at MD Anderson Cancer Center showed a higher rate of cancer recurrence using APBI, requiring a mastectomy. We await the results of more definitive studies being conducted throughout the world to get the final word on this. You can read about these various experimental techniques of APBI here. Randomized clinical trials are being conducted to evaluate the effectiveness of this treatment, and until then, only women who are not candidates for the clinical trial should be considered for APBI off-study. Selected women who are at the lowest risk of recurrence (recurrence means the cancer coming back) may be offered APBI. Researchers at MD Anderson Cancer Center showed a higher rate of cancer recurrence using APBI, requiring a mastectomy. We await the results of more definitive studies being conducted throughout the world to get the final word on this.

Who is a candidate for accelerated partial breast radiation and what are the disadvantages versus whole breast radiation?

Selected women who are at the lowest risk of recurrence (recurrence means the cancer coming back) may be offered APBI. This includes women who are older than age 60, with small cancers under 1 inch in size, located in just one spot of the breast, which were removed with wide margins of cancer-free tissue surrounding it, and those that do not have certain features when looking at the cancer under the microscope. While women fitting these criteria may do well, in general, about 1 in 3 women have cancer cells in the rest of the breast that is best treated with radiation to the whole breast. Whole breast radiation is like an insurance policy that these other cells will be killed once and for all, and studies may very well show superiority of this approach.

Women who are concerned about cosmetic outcome should be aware that whole breast radiation has been shown to have better cosmetic outcomes than APBI. This data was presented at a national meeting (ASTRO) in the end of 2012.

What is accelerated whole breast radiation?

This is a relatively new method for giving radiation to the whole breast developed and used in Canada and England. It has gained popularity in the USA since it provides the advantages of whole breast radiation but saves two to three weeks of time on average compared to traditional whole breast radiation. Not all women are ideal candidates for this technique, for example younger women less than 70 and women with triple negative breast cancer. Most clinical trial data show that the cosmetic results are excellent with this technique, in contrast to APBI above where some women have been noted to suffer serious cosmetic late effects such as significant scarring and occasionally requiring surgery to remove dead breast fat causing pain (called 'fat necrosis')

How does the newest technology we have help to get better results compared to centers with older equipment?

Modern radiation involves computer controlled dose modulation that can actually reduce extremes in radiation in the breast and on the skin such that the dose is much more homogenous and you experience less skin burning. More importantly it allows for better heart and lung protection. The breast also has less areas of under dosing so tumor control is expected to be higher.

GLOSSARY OF COMMON TERMS

4-D RADIATION THERAPY:

4DRT employs advanced technology to track and compensate for target motion during radiation treatment, minimizing normal tissue injury, especially to adjacent critical structures, while maximizing radiation dose to the target.

ADJUVANT THERAPY:

A cancer treatment that comes AFTER your first (or primary) treatment. For example, you may have an operation (surgery), followed by radiation or chemotherapy. The radiation or chemotherapy would be called an adjuvant therapy.

ANEMIA:

A decrease in the number of red blood cells. Signs and symptoms include tiredness, pale skin, shortness of breath.

BIOLOGICAL RESPONSE MODIFIERS:

Drugs used to change the body's immune response to cancer cells.

BONE MARROW TRANSPLANT:

Injecting bone marrow into a patient from either a donor or stored marrow from the patient. This helps people to grow new bone cells after very high doses of chemotherapy and/or radiation therapy.

BRACHYTHERAPY:

Wires, seeds or needles that have a source of radiation inside them. These wires, seeds or needles are put into a cancer tumor, or into a place where a cancer tumor used to be. They are left there for a period of time.

CBC:

(Complete Blood Count) A blood test that measures the number of white blood cells, red blood cells and platelets.

CHEMOTHERAPY:

The use of drugs to treat cancer, often called chemo.

CLINICAL TRIAL:

A clinical trial is a research study with cancer patients to learn about new treatments and to find better ways of giving current treatments.

COMPUTED TOMOGRAPHY (CT):

A CT scan uses X-rays to produce detailed pictures of structures inside the body. The process is also known as a computerized axial tomography (CAT) scan. The imaging works by using computer processing to generate an image of the absorption of X-rays in a field of view. The field of view is devised as a slice so that a complete examination of the brain or body may be obtained by taking a series of slices, one above the other.

FRACTIONATION:

A term used when the total dose of radiation is divided into smaller doses, generally given over a period of days to give normal healthy cells time to heal.

GAMMA RAYS:

A type of radiation of shorter wavelength and higher energy than kilovoltage X-rays used for diagnosis characterized by the fact it was generated by a radioactive isotope.

HORMONE THERAPY:

The use of hormones (given as drugs) to treat some kinds of cancer.

HYPOFRACTIONATION:

Small doses of radiation delivered during multiple treatment sessions that extend over several days. Hypofractionation is necessary when the full dose cannot be confined to the target area; use of smaller doses helps to minimize the damage to the tissue around the target, and multiple days allows it to recover from the radiation dose it receives.

IGRT:

Image-guided radiation therapy is a technology advancement that enables the use of frequent imaging during a course of radiation therapy to support precision and accuracy in areas prone to movement, such as lungs and prostate gland, as well as for tumors located close to critical organs and tissues.

IMRT:

Intensity-modulated radiation therapy is an advanced mode of radiotherapy that allows computer-controlled radiation intensity to be changed (modulated) during treatment to support three-dimensional treatment precision and accuracy.

ISOCENTER:

A point in space defined by the intersection of all the machine-based axis of rotation where radiation is directed in a highly reproducible and accurate way. The isocenter remains constant and therefore is easily quality-assured on a routine basis. A single isocenter consists of many simultaneously delivered beams of radiation.

LINEAR ACCELERATOR:

A machine that is used in radiation treatment that may also be called a linac. It uses high energy x-rays to treat cancer.

MAGNETIC RESONANCE IMAGING (MRI OR MR):

MRI provides three-dimensional, or multiplanar, views of an internal organ or structure. MRI offers increased-contrast resolution, enabling better visualization of soft tissues such as the brain and spinal cord.

METASTASIS:

This is when cancer cells in one place (the breast, for example) spread to other parts of the body such as the liver, bones, lungs or brain.

MULTI-LEAF COLLIMATOR (MLC):

A device within a linear accelerator made up of tungsten leaves that can move independently to provide conformal shaping of radiation beams.

OBS OR REVIEW CLINIC:

The weekly visit with the doctor or nurse while you are receiving radiation.

ONCOLOGIST:

A physician who specializes in the diagnosis and treatment of cancer.

ORTHOVOLTAGE:

A machine used in radiation treatment to treat cancers that are on the surface, or close to the surface, of your body.

PALLIATIVE CARE:

The goal of palliative care is to improve the quality of life for people with cancer and their families.

RADIATION TREATMENT (OR THERAPY):

This is the use of radiation to destroy cancer cells. The most common kinds of radiation used are high energy X-rays, gamma rays and electrons.

RADIOSURGERY:

Radiosurgery is the delivery of a single high dose of radiation to a target in a single session by using multiple, focused, finely collimated radiation beams with surgical precision.

RADIOTHERAPY OR RADIATION THERAPY:

The use of high-energy radiation from X-rays, gamma rays, neutrons and other sources to kill cancer cells and shrink tumors.

RED BLOOD CELLS:

The cells in the blood that carry oxygen to different parts of the body.

SBRT:

Stereotactic body radiation therapy is a highly specialized form of external beam radiation therapy combining advanced technology and expert technique. In SBRT, exact localization of tumors enables delivery of precisely focused radiation at higher potency doses and over fewer treatments than conventional radiation therapy, to maximize achievable outcomes with minimal collateral damage.

SIMULATION (OR SIM):

The initial planning of the radiation treatment that is done on a similar machine to the radiation machine.

SURGERY:

The use of operating procedures to correct deformities, repair injuries, or remove certain diseased tissues.

X-RAY:

A form of electromagnetic radiation that creates images as x-ray particles pass through the body. Space

Contact Florida Breast Conservation

at Terk Oncology

Call: (888) 339-0588

7017 AC Skinner Parkway
Jacksonville, FL 32256

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